Salsalate reduces atherosclerosis through AMPKβ1 in mice

• Main Authors: Emily A. Day (Author), Rebecca J. Ford (Author), Brennan K. Smith (Author), Vanessa P. Houde (Author), Stephanie Stypa (Author), Sonia Rehal (Author), Sarka Lhotak (Author), Bruce E. Kemp (Author), Bernardo L. Trigatti (Author), Geoff H. Werstuck (Author), Richard C. Austin (Author), Morgan D. Fullerton (Author), Gregory R. Steinberg (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Salsalate is a prodrug of salicylate that lowers blood glucose in people with type 2 diabetes. AMP-activated protein kinase (AMPK) is an αβγ heterotrimer which inhibits macrophage inflammation and the synthesis of fatty acids and cholesterol in the liver through phosphorylation of acetyl-...