The brain protection of MLKL inhibitor necrosulfonamide against focal ischemia/reperfusion injury associating with blocking the nucleus and nuclear envelope translocation of MLKL and RIP3K

• Main Authors: Xian-Yong Zhou (Author), Bo Lin (Author), Wei Chen (Author), Rui-Qi Cao (Author), Yi Guo (Author), Ali Said (Author), Taous Khan (Author), Hui-Ling Zhang (Author), Yong-Ming Zhu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mixed lineage kinase like protein (MLKL) is a key mediator of necroptosis. While previous studies highlighted the important role of MLKL as one of the central regulators of brain damage against acute ischemic neuronal injury, how the activation of MLKL mediates brain injuries and cell death remains...