Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) Attenuates Myocardial Fibrosis in Post-heterotopic Heart Transplantation

• Main Authors: Naseer Ahmed (Author), Daniele Linardi (Author), Nazeer Muhammad (Author), Cristiano Chiamulera (Author), Guido Fumagalli (Author), Livio San Biagio (Author), Mebratu A. Gebrie (Author), Muhammad Aslam (Author), Giovanni Battista Luciani (Author), Giuseppe Faggian (Author), Alessio Rungatscher (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Objective: Sphingosine 1-phosphate (S1P), and S1P receptor modulator fingolimod have been suggested to play important cardioprotective role in animal models of myocardial ischemia/reperfusion injuries. To understand the cardioprotective function of S1P and its mechanism in vivo, we an...