Mitochondrial Protein Akap1 Deletion Exacerbates Endoplasmic Reticulum Stress in Mice Exposed to Hyperoxia

• Main Authors: Sahebgowda Sidramagowda Patil (Author), Ramani Soundararajan (Author), Jutaro Fukumoto (Author), Mason Breitzig (Author), Helena Hernández-Cuervo (Author), Matthew Alleyn (Author), Muling Lin (Author), Venkata Ramireddy Narala (Author), Richard Lockey (Author), Narasaiah Kolliputi (Author), Lakshmi Galam (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute lung injury (ALI) and its severe manifestation, acute respiratory distress syndrome (ARDS), are treated with high concentrations of supplementary oxygen. However, prolonged exposure to high oxygen concentrations stimulates the production of reactive oxygen species (ROS), which damages the mito...