Triptolide and l-ascorbate palmitate co-loaded micelles for combination therapy of rheumatoid arthritis and side effect attenuation

• Main Authors: Man Li (Author), Guoqiang Wang (Author), Yinyin Yan (Author), Mengyuan Jiang (Author), Zhirong Wang (Author), Zhenqiang Zhang (Author), Xiangxiang Wu (Author), Huahui Zeng (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triptolide (TP) has its unique curative effect in the treatment of rheumatoid arthritis (RA), but its application is limited by the poor water solubility and multi-organ toxicity. We herein developed a novel nanoparticle platform composed of L-ascorbate palmitate (VP, vitamin C derivative) that can...