Combination of Rapamycin and MK-2206 Induced Cell Death via Autophagy and Necroptosis in MYCN-Amplified Neuroblastoma Cell Lines

• Váldodahkkit: Yudi Dong (Dahkki), Wei Gong (Dahkki), Zhongyan Hua (Dahkki), Bo Chen (Dahkki), Guifeng Zhao (Dahkki), Zhihui Liu (Dahkki), Carol J. Thiele (Dahkki), Zhijie Li (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Neuroblastoma (NB) is the most common pediatric malignant extracranial solid tumor. Despite multi-modality therapies, the emergence of drug resistance is an obstacle in the treatment of high-risk NB patients (with MYCN amplification). In our previous study, we found that rapamycin and MK-2206 synerg...