Combination of Rapamycin and MK-2206 Induced Cell Death via Autophagy and Necroptosis in MYCN-Amplified Neuroblastoma Cell Lines

• Autori principali: Yudi Dong (Autore), Wei Gong (Autore), Zhongyan Hua (Autore), Bo Chen (Autore), Guifeng Zhao (Autore), Zhihui Liu (Autore), Carol J. Thiele (Autore), Zhijie Li (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Neuroblastoma (NB) is the most common pediatric malignant extracranial solid tumor. Despite multi-modality therapies, the emergence of drug resistance is an obstacle in the treatment of high-risk NB patients (with MYCN amplification). In our previous study, we found that rapamycin and MK-2206 synerg...