Pharmacokinetics and Nephrotoxicity of Polymyxin MRX-8 in Rats: A Novel Agent against Resistant Gram-Negative Bacteria

• Những tác giả chính: Xingyi Qu (Tác giả), Chenxue Guo (Tác giả), Shaojun Liu (Tác giả), Xin Li (Tác giả), Lin Xi (Tác giả), Xiaofen Liu (Tác giả), Jing Zhang (Tác giả)
• Định dạng: Sách
• Được phát hành: MDPI AG, 2024-04-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

MRX-8 is a novel polymyxin for carbapenem-resistant Gram-negative infections that has been recently evaluated in Phase I clinical trials. Herein, its pharmacokinetics (PK) and nephrotoxicity in rats are reported for the first time. This study aimed at pre-clinical PK and safety assessments. An LC-MS...