Synthesis, Structure-Activity Relationships and In Vitro Toxicity Profile of Lactose-Based Fatty Acid Monoesters as Possible Drug Permeability Enhancers

• Main Authors: Simone Lucarini (Author), Laura Fagioli (Author), Robert Cavanagh (Author), Wanling Liang (Author), Diego Romano Perinelli (Author), Mario Campana (Author), Snjezana Stolnik (Author), Jenny K. W. Lam (Author), Luca Casettari (Author), Andrea Duranti (Author)
• Format: Book
• Published: MDPI AG, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Permeability enhancers are receiving increased attention arising from their ability to increase transepithelial permeability and thus, bioavailability of orally or pulmonary administered biopharmaceutics. Here we present the synthesis and the in vitro assaying of a series of lactose-based non-ionic...