Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor

Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor

Protein kinase CK2 is associated with a number of human diseases, among them cancer, and is therefore a target for inhibitor development in industry and academia. Six crystal structures of either CK2α, the catalytic subunit of human protein kinase CK2, or its paralog CK2α' in complex with two A...

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Main Authors: Karsten Niefind (Author), Nils Bischoff (Author), Andriy G. Golub (Author), Volodymyr G. Bdzhola (Author), Anatoliy O. Balanda (Author), Andriy O. Prykhod'ko (Author), Sergiy M. Yarmoluk (Author)
Format: Book
Published: MDPI AG, 2017-01-01T00:00:00Z.
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