Antimicrobial Activity of Aztreonam in Combination with Old and New β-Lactamase Inhibitors against MBL and ESBL Co-Producing Gram-Negative Clinical Isolates: Possible Options for the Treatment of Complicated Infections

• Main Authors: Gianluca Morroni (Author), Raffaela Bressan (Author), Simona Fioriti (Author), Gloria D'Achille (Author), Marina Mingoia (Author), Oscar Cirioni (Author), Stefano Di Bella (Author), Aurora Piazza (Author), Francesco Comandatore (Author), Carola Mauri (Author), Roberta Migliavacca (Author), Francesco Luzzaro (Author), Luigi Principe (Author), Cristina Lagatolla (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metallo-β-lactamases (MBLs) are among the most challenging bacterial enzymes to overcome. Aztreonam (ATM) is the only β-lactam not hydrolyzed by MBLs but is often inactivated by co-produced extended-spectrum β-lactamases (ESBL). We assessed the activity of the combination of ATM with old and new β-l...