Mutation of aspartic acid 262 on estrogen receptor abrogates estradiol signaling pathway

• 主要な著者: Xingyan Xu (著者), Haowei Yu (著者), Shuihao Zhu (著者), Ping Li (著者), Xiaosa Li (著者), Yongqi Gao (著者), Yixiao Xiang (著者), Guojun Zhao (著者), Tommaso Simoncini (著者), Huiping Lin (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Objective ERα (estrogen receptor alpha) exerts nuclear genomic actions and membrane-initiated non-genomic effects. The mutation of aspartic acid into alanine in vitro revealed the critical role of aspartic acid 258 (corresponding to mouse amino acid site 262) of ERα for non-nuclear function. Our pre...