Mutation of aspartic acid 262 on estrogen receptor abrogates estradiol signaling pathway

• Main Authors: Xingyan Xu (Author), Haowei Yu (Author), Shuihao Zhu (Author), Ping Li (Author), Xiaosa Li (Author), Yongqi Gao (Author), Yixiao Xiang (Author), Guojun Zhao (Author), Tommaso Simoncini (Author), Huiping Lin (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective ERα (estrogen receptor alpha) exerts nuclear genomic actions and membrane-initiated non-genomic effects. The mutation of aspartic acid into alanine in vitro revealed the critical role of aspartic acid 258 (corresponding to mouse amino acid site 262) of ERα for non-nuclear function. Our pre...