Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity

Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity

A series of 5-benzylamine-substituted pyrimido[4,5-c]quinoline derivatives of the CSNK2A chemical probe SGC-CK2-2 were synthesized with the goal of improving kinase inhibitor cellular potency and antiviral phenotypic activity while maintaining aqueous solubility. Among the range of analogs, those be...

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Main Authors: Kesatebrhan Haile Asressu (Author), Jeffery L. Smith (Author), Rebekah J. Dickmander (Author), Nathaniel J. Moorman (Author), James Wellnitz (Author), Konstantin I. Popov (Author), Alison D. Axtman (Author), Timothy M. Willson (Author)
Format: Book
Published: MDPI AG, 2024-02-01T00:00:00Z.
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3rd Floor Main Library

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