Development of a neonatal Göttingen Minipig model for dose precision in perinatal asphyxia: technical opportunities, challenges, and potential further steps

• Autores principales: Marina-Stefania Stroe (Autor), Lieselotte Van Bockstal (Autor), Allan Valenzuela (Autor), Miriam Ayuso (Autor), Karen Leys (Autor), Pieter Annaert (Autor), Sebastien Carpentier (Autor), Anne Smits (Autor), Karel Allegaert (Autor), Adrian Zeltner (Autor), Antonius Mulder (Autor), Chris Van Ginneken (Autor), Steven Van Cruchten (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Animal models provide useful information on mechanisms in human disease conditions, but also on exploring (patho)physiological factors affecting pharmacokinetics, safety, and efficacy of drugs in development. Also, in pediatric patients, nonclinical data can be critical for better understanding the...