Diclofenac and other non-steroidal anti-inflammatory drugs (NSAIDs) are competitive antagonists of the human P2X3 receptor

• Main Authors: Laura Grohs (Author), Linhan Cheng (Author), Saskia Cönen (Author), Bassam G. Haddad (Author), Astrid Bülow (Author), Idil Toklucu (Author), Lisa Ernst (Author), Jannis Körner (Author), Günther Schmalzing (Author), Angelika Lampert (Author), Jan-Philipp Machtens (Author), Ralf Hausmann (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: The P2X3 receptor (P2X3R), an ATP-gated non-selective cation channel of the P2X receptor family, is expressed in sensory neurons and involved in nociception. P2X3R inhibition was shown to reduce chronic and neuropathic pain. In a previous screening of 2000 approved drugs, natural produ...