ATGL-1 mediates the effect of dietary restriction and the insulin/IGF-1 signaling pathway on longevity in C. elegans

• Main Authors: Nava Zaarur (Author), Kathleen Desevin (Author), James Mackenzie (Author), Avery Lord (Author), Alla Grishok (Author), Konstantin V. Kandror (Author)
• 格式: 图书
• 出版: Elsevier, 2019-09-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Objective: Animal lifespan is controlled through genetic pathways that are conserved from nematodes to humans. Lifespan-promoting conditions in nematodes include fasting and a reduction of insulin/IGF signaling. Here we aimed to investigate the input of the Caenorhabditis elegans homologue of the ma...