Interaction between DNA and Drugs Having Protonable Basic Groups: Characterization through Affinity Constants, Drug Release Kinetics, and Conformational Changes

• Váldodahkkit: Liliana P. Alarcón (Dahkki), Yolima Baena (Dahkki), Rubén H. Manzo (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2017-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

This paper reports the in vitro characterization of the interaction between the phosphate groups of DNA and the protonated species of drugs with basic groups through the determination of the affinity constants, the reversibility of the interaction, and the effect on the secondary structure of the ma...