<i>In Vitro</i> Assessment of Drug-Induced Liver Injury Using Cell-Based Models: A Review

• Tác giả chính: I. A. Mazerkina (Tác giả)
• Định dạng: Sách
• Được phát hành: Ministry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products», 2023-06-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Drug-induced liver injury (DILI) is the reason for 15-18% of medicinal product recalls from the market. Since interspecies differences often limit the relevance of standard non-clinical tests in vivo, a promising alternative is to develop cell-based in vitro methods.The aim of the study was to revie...