EXT418, a novel long‐acting ghrelin, mitigates Lewis lung carcinoma induced cachexia in mice

• Main Authors: Haiming L. Kerr (Author), Kora Krumm (Author), Ian (In‐gi) (Author), Barbara Anderson (Author), Anthony Christiani (Author), Lena Strait (Author), Beatrice A. Breckheimer (Author), Brynn Irwin (Author), Alice (Siyi) (Author), Artur Rybachok (Author), Amanda Chen (Author), Lucas Caeiro (Author), Elizabeth Dacek (Author), Daniel B. Hall (Author), Caroline H. Kostyla (Author), Laura M. Hales (Author), Tarik M. Soliman (Author), Jose M. Garcia (Author)
• Format: Book
• Published: Wiley, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Ghrelin is a potential therapy for cachexia due to its orexigenic properties and anabolic effects on muscle and fat. However, its clinical use is limited by the short half‐life of active (acylated) ghrelin (~11 min in humans). EXT418 is a novel long‐acting, constitutively active...