Involvement of cyclic guanosine monophosphate-dependent protein kinase I in renal antifibrotic effects of serelaxin

• Главные авторы: Veronika Wetzl (Автор), Elisabeth Schinner (Автор), Frieder Kees (Автор), Franz Hofmann (Автор), Lothar Faerber (Автор), Jens Schlossmann (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2016-07-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Introduction: Kidney fibrosis has shown to be ameliorated through the involvement of cyclic guanosine monophosphate (cGMP) and its dependent protein kinase I (cGKI). Serelaxin, the recombinant form of human relaxin-II, increases cGMP levels and has shown beneficial effects on kidney function in acut...