E-selectin Targeting PEGylated-thioaptamer Prevents Breast Cancer Metastases

• Main Authors: Yoshihiro Morita (Author), Mohamed Kamal (Author), Shin-Ae Kang (Author), Roy Zhang (Author), Ganesh LR Lokesh (Author), Varatharasa Thiviyanathan (Author), Nafis Hasan (Author), Sukyung Woo (Author), Daniel Zhao (Author), Macall Leslie (Author), Stephen Suh (Author), Wajeeha Razaq (Author), Hallgeir Rui (Author), David G Gorenstein (Author), David E Volk (Author), Takemi Tanaka (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

E-selectin is an adhesion molecule expressed on the luminal surface of inflamed blood vessels that mediates hematogenous metastasis by assisting shear-resistant adhesion of circulating tumor cells to the vessel surface under dynamic blood flow. Previously, we developed an E-selectin antagonistic thi...