Pharmacokinetics of H002, a novel S1PR1 modulator, and its metabolites in rat blood using liquid chromatography-tandem mass spectrometry

• Main Authors: Jiaqi Mi (Author), Manman Zhao (Author), Shu Yang (Author), Shuang Yang (Author), Jing Jin (Author), Xiaojian Wang (Author), Qiong Xiao (Author), Jinping Hu (Author), Yan Li (Author)
• Format: Book
• Published: Elsevier, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of H002 and its phosphorylated metabolite, H002-P and hydroxylated metabolite H002-M, in rat blood. H001, an analogue of H002, was used as the interna...