Inhibition of Lactate Dehydrogenase-A by Singlet Oxygen and Hypochlorous Acid via Cysteine Oxidation and Irreversible Conformational Changes
Muscle lactate dehydrogenase (LDH-A) catalyzes the reduction of pyruvate to lactate, the end product of anaerobic glycolysis. LDH-A is overexpressed in many cancers prior to and even when tumors receive adequate oxygen, and lactate has multiple cellular roles. We assessed the effect of singlet oxyge...
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| Main Authors: | , , |
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| Format: | Book |
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MDPI AG,
2024-02-01T00:00:00Z.
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| Call Number: |
A1234.567 |
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| Copy 1 | Available |