lncRNA HotairM1 Depletion Promotes Self-Renewal of Cancer Stem Cells through HOXA1-Nanog Regulation Loop

• Autori principali: Fang Li (Autore), Yangfan Xu (Autore), Xiaofang Xu (Autore), Shengfang Ge (Autore), Feifei Zhang (Autore), He Zhang (Autore), Xianqun Fan (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2020-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

In cancer cells, a gain of stemness may have profound implications for tumor initiation, aggressiveness, and clinical outcome. However, the molecular mechanisms underlying the self-renewal maintenance of cancer stem-like cells (CSCs) remain elusive. Here, based on analysis of transcriptome sequencin...