A Comprehensive Overview of Globally Approved JAK Inhibitors

• Autors principals: Ahmed M. Shawky (Autor), Faisal A. Almalki (Autor), Ashraf N. Abdalla (Autor), Ahmed H. Abdelazeem (Autor), Ahmed M. Gouda (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2022-05-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling through the JAK-STAT pathway, which regulates the transcription of several genes involved in inflammatory, immune, and canc...