Combined Treatment With 2-(2-Benzofu-Ranyl)-2-Imidazoline and Recombinant Tissue Plasminogen Activator Protects Blood-Brain Barrier Integrity in a Rat Model of Embolic Middle Cerebral Artery Occlusion

Recombinant tissue plasminogen activator (rt-PA) is used to treat acute ischemic stroke but is only effective if administered within 4.5 h after stroke onset. Delayed rt-PA treatment causes blood-brain barrier (BBB) disruption and hemorrhagic transformation. The compound 2-(-2-benzofuranyl)-2-imidaz...

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Main Authors: Linlei Zhang (Author), Shasha Xu (Author), Xiaoxiao Wu (Author), Jiaou Chen (Author), Xiaoling Guo (Author), Yungang Cao (Author), Zheng Zhang (Author), Jueyue Yan (Author), Jianhua Cheng (Author), Zhao Han (Author)
Format: Knjiga
Izdano: Frontiers Media S.A., 2020-06-01T00:00:00Z.
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