PAR2 activation on human tubular epithelial cells engages converging signaling pathways to induce an inflammatory and fibrotic milieu

PAR2 activation on human tubular epithelial cells engages converging signaling pathways to induce an inflammatory and fibrotic milieu

Key features of chronic kidney disease (CKD) include tubulointerstitial inflammation and fibrosis. Protease activated receptor-2 (PAR2), a G-protein coupled receptor (GPCR) expressed by the kidney proximal tubular cells, induces potent proinflammatory responses in these cells. The hypothesis tested...

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Main Authors: David A. Vesey (Author), Abishek Iyer (Author), Evan Owen (Author), Danielle Kamato (Author), David W. Johnson (Author), Glenda C. Gobe (Author), David P. Fairlie (Author), David J. Nikolic-Paterson (Author)
Format: Book
Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
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