Detoxification Genomics in Children with β-Thalassemia Major: Pilot Study of Glutathione S Transferase M1, Pi & Methyltetrahydrofolate Reductase Gene Polymorphisms Combinations in β- Thalassemia Major

• Main Authors: Magd A. Kotb (Author), Mona Hamdy (Author), Khaled Eid (Author), Mona Aziz (Author), Mai Abd El Salam (Author), Hend Abd El Baky (Author), Nabil Lotfi (Author), Niveen Salama (Author)
• Format: Book
• Published: Cairo University, Faculty of Medicine, Department of Pediatrics, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Children with β-thalassemia major differ regarding age at presentation, transfusion requirements and unpredictable timing, rate and severity of hemolytic crisis. The blood transfusions are associated with iron overload. Glutathione S transferase M1 (GSTM1) null mutation was reported to b...