Targeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy

• Main Authors: Yue Zhang (Author), Jingwen Gao (Author), Na Li (Author), Peng Xu (Author), Shimeng Qu (Author), Jinqian Cheng (Author), Mingrui Wang (Author), Xueru Li (Author), Yaheng Song (Author), Fan Xiao (Author), Xinyu Yang (Author), Jihong Liu (Author), Hao Hong (Author), Ronghao Mu (Author), Xiaotian Li (Author), Youmei Wang (Author), Hui Xu (Author), Yuan Xie (Author), Tianming Gao (Author), Guangji Wang (Author), Jiye Aa (Author)
• Format: Book
• Published: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Studies have suggested that the nucleus accumbens (NAc) is implicated in the pathophysiology of major depression; however, the regulatory strategy that targets the NAc to achieve an exclusive and outstanding anti-depression benefit has not been elucidated. Here, we identified a specific reduction of...