Manipulation of Lipid Nanocapsules as an Efficient Intranasal Platform for Brain Deposition of Clozapine as an Antipsychotic Drug

• Main Authors: Ahmed A. Katamesh (Author), Hend Mohamed Abdel-Bar (Author), Mohammed Khaled Bin Break (Author), Shimaa M. Hassoun (Author), Gehad Subaiea (Author), Amr Radwan (Author), Hadel A. Abo El-Enin (Author)
• Format: Book
• Published: MDPI AG, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/objectives: The blood-brain barrier (BBB) significantly limits the treatment of central nervous system disorders, such as schizophrenia, by restricting drug delivery to the brain. This study explores the potential of intranasal clozapine-loaded lipid nanocapsules (IN LNCs<sub>Clo<...