The role of haploinsufficiency of RPS14 and p53 activation in the molecular pathogenesis of the 5q- syndrome
In recent years we have gained great insight into the molecular pathogenesis of the 5q- syndrome, a distinct subtype of myelodysplasia. The demonstration of haploinsufficiency of the ribosomal gene RPS14 (mapping to the commonly deleted region) and the finding that this is the cause of the erythroid...
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MDPI AG,
2011-06-01T00:00:00Z.
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