Identification of Potent and Selective JAK1 Lead Compounds Through Ligand-Based Drug Design Approaches

• Asıl Yazarlar: Sathya Babu (Yazar), Santhosh Kumar Nagarajan (Yazar), Sruthy Sathish (Yazar), Vir Singh Negi (Yazar), Honglae Sohn (Yazar), Thirumurthy Madhavan (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

JAK1 plays a significant role in the intracellular signaling by interacting with cytokine receptors in different types of cells and is linked to the pathogenesis of various cancers and in the pathology of the immune system. In this study, ligand-based pharmacophore modeling combined with virtual scr...