Nimbolide-based nanomedicine inhibits breast cancer stem-like cells by epigenetic reprogramming of DNMTs-SFRP1-Wnt/β-catenin signaling axis

• Main Authors: Priyanka Mohapatra (Author), Swati Madhulika (Author), Somalisa Behera (Author), Priya Singh (Author), Pratikshya Sa (Author), Punit Prasad (Author), Rajeeb Kumar Swain (Author), Sanjeeb Kumar Sahoo (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triple-negative breast cancer (TNBC) harbors a high percentage of breast cancer stem-like cells (BCSCs) that significantly contribute to poor prognosis, metastasis, and relapse of the disease. Thus, targeting BCSCs could be a promising approach to combat TNBC. In this context, we investigated nimbol...