17β-Estradiol Enhances Schwann Cell Differentiation via the ERβ-ERK1/2 Signaling Pathway and Promotes Remyelination in Injured Sciatic Nerves

• Main Authors: Yun Gu (Author), Yumen Wu (Author), Wenfeng Su (Author), LingYan Xing (Author), Yuntian Shen (Author), Xiaowen He (Author), Lilan Li (Author), Ying Yuan (Author), Xin Tang (Author), Gang Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Remyelination is critical for nerve regeneration. However, the molecular mechanism involved in remyelination is poorly understood. To explore the roles of 17β-estradiol (E2) for myelination in the peripheral nervous system, we used a co-culture model of rat dorsal root ganglion (DRG) explants and Sc...