The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds

• Main Authors: Nils-Jørgen Knudsen Dal (Author), Martin Speth (Author), Kerstin Johann (Author), Matthias Barz (Author), Claire Beauvineau (Author), Jens Wohlmann (Author), Federico Fenaroli (Author), Brigitte Gicquel (Author), Gareth Griffiths (Author), Noelia Alonso-Rodriguez (Author)
• Format: Book
• Published: The Company of Biologists, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

With the increasing emergence of drug-resistant Mycobacterium tuberculosis strains, new and effective antibiotics against tuberculosis (TB) are urgently needed. However, the high frequency of poorly water-soluble compounds among hits in high-throughput drug screening campaigns is a major obstacle in...