The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds

• 主要な著者: Nils-Jørgen Knudsen Dal (著者), Martin Speth (著者), Kerstin Johann (著者), Matthias Barz (著者), Claire Beauvineau (著者), Jens Wohlmann (著者), Federico Fenaroli (著者), Brigitte Gicquel (著者), Gareth Griffiths (著者), Noelia Alonso-Rodriguez (著者)
• フォーマット: 図書
• 出版事項: The Company of Biologists, 2022-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

With the increasing emergence of drug-resistant Mycobacterium tuberculosis strains, new and effective antibiotics against tuberculosis (TB) are urgently needed. However, the high frequency of poorly water-soluble compounds among hits in high-throughput drug screening campaigns is a major obstacle in...