A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug‐induced toxicity

• Main Authors: Louis Gall (Author), Ferran Jardi (Author), Lieve Lammens (Author), Janet Piñero (Author), Terezinha M. Souza (Author), Daniela Rodrigues (Author), Danyel G. J. Jennen (Author), Theo M. deKok (Author), Luke Coyle (Author), Seung‐Wook Chung (Author), Sofia Ferreira (Author), Heeseung Jo (Author), Kylie A. Beattie (Author), Colette Kelly (Author), Carrie A. Duckworth (Author), D. Mark Pritchard (Author), Carmen Pin (Author)
• Format: Book
• Published: Wiley, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract We have built a quantitative systems toxicology modeling framework focused on the early prediction of oncotherapeutic‐induced clinical intestinal adverse effects. The model describes stem and progenitor cell dynamics in the small intestinal epithelium and integrates heterogeneous epithelial...