Pharmacokinetic Evaluation of a DSPE-PEG2000 Micellar Formulation of Ridaforolimus in Rat

• Main Authors: Marcus Laird Forrest (Author), Yunqi Zhao (Author), Jody K. Takemoto (Author), Rebecca M. Bertram (Author), Connie M. Remsberg (Author), Neal M. Davies (Author)
• Format: Book
• Published: MDPI AG, 2012-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The rapamycin analog, ridaforolimus, has demonstrated potent anti-proliferative effects in cancer treatment, and it currently is being evaluated in a range of clinical cancer studies. Ridaforolimus is an extremely lipophilic compound with limited aqueous solubility, which may benefit from formulatio...