Uncovering the Functional Link Between SHANK3 Deletions and Deficiency in Neurodevelopment Using iPSC-Derived Human Neurons

• Main Authors: Guanqun Huang (Author), Shuting Chen (Author), Xiaoxia Chen (Author), Jiajun Zheng (Author), Zhuoran Xu (Author), Abolfazl Doostparast Torshizi (Author), Siyi Gong (Author), Qingpei Chen (Author), Xiaokuang Ma (Author), Jiandong Yu (Author), Libing Zhou (Author), Shenfeng Qiu (Author), Kai Wang (Author), Lingling Shi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SHANK3 mutations, including de novo deletions, have been associated with autism spectrum disorders (ASD). However, the effects of SHANK3 loss of function on neurodevelopment remain poorly understood. Here we generated human induced pluripotent stem cells (iPSC) in vitro, followed by neuro-differenti...