Uncovering the Functional Link Between SHANK3 Deletions and Deficiency in Neurodevelopment Using iPSC-Derived Human Neurons
SHANK3 mutations, including de novo deletions, have been associated with autism spectrum disorders (ASD). However, the effects of SHANK3 loss of function on neurodevelopment remain poorly understood. Here we generated human induced pluripotent stem cells (iPSC) in vitro, followed by neuro-differenti...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Book |
| Published: |
Frontiers Media S.A.,
2019-03-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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