MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo

• Main Authors: Karolin Walter (Author), Kanishka Tiwary (Author), Marija Trajkovic-Arsic (Author), Ana Hidalgo-Sastre (Author), Laura Dierichs (Author), Sven T. Liffers (Author), Jiangning Gu (Author), Johann Gout (Author), Lucas-Alexander Schulte (Author), Jan Münch (Author), Thomas Seufferlein (Author), Bruno Sainz (Author), Jens T. Siveke (Author), Eva Rodriguez-Aznar (Author), Patrick C. Hermann (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic ductal adenocarcinoma (PDAC) remains a devastating disease with a very poor prognosis. At the same time, its incidence is on the rise, and PDAC is expected to become the second leading cause of cancer-related death by 2030. Despite extensive work on new therapeutic approaches, the median...