MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo

• Prif Awduron: Karolin Walter (Awdur), Kanishka Tiwary (Awdur), Marija Trajkovic-Arsic (Awdur), Ana Hidalgo-Sastre (Awdur), Laura Dierichs (Awdur), Sven T. Liffers (Awdur), Jiangning Gu (Awdur), Johann Gout (Awdur), Lucas-Alexander Schulte (Awdur), Jan Münch (Awdur), Thomas Seufferlein (Awdur), Bruno Sainz (Awdur), Jens T. Siveke (Awdur), Eva Rodriguez-Aznar (Awdur), Patrick C. Hermann (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Hindawi Limited, 2019-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Pancreatic ductal adenocarcinoma (PDAC) remains a devastating disease with a very poor prognosis. At the same time, its incidence is on the rise, and PDAC is expected to become the second leading cause of cancer-related death by 2030. Despite extensive work on new therapeutic approaches, the median...