Design, synthesis, and evaluation of novel benzoylhydrazone derivatives as Nur77 modulators with potent antitumor activity against hepatocellular carcinoma

Nur77 modulators have emerged as a promising therapeutic approach for hepatocellular carcinoma. In this study, a structure-based rational drug design approach was used to design and synthesise a series of 4-((8-hydroxy-2-methylquinolin-4-yl)amino)benzoylhydrazone derivatives based on the binding cha...

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Main Authors: Fengming He (Author), Jun Chen (Author), Taige Zhao (Author), Qiaoqiong Wu (Author), Na Yin (Author), Xiumei Wang (Author), Yijing Zhong (Author), Xiaodan Guo (Author), YingKun Qiu (Author), Baicun Li (Author), Meijuan Fang (Author), Zhen Wu (Author)
Format: Book
Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
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