The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets

• Main Authors: Kevin Vivot (Author), Valentine S. Moullé (Author), Bader Zarrouki (Author), Caroline Tremblay (Author), Arturo D. Mancini (Author), Hasna Maachi (Author), Julien Ghislain (Author), Vincent Poitout (Author)
• Format: Book
• Published: Elsevier, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: G protein-coupled receptor (GPCR) signaling regulates insulin secretion and pancreatic β cell-proliferation. While much knowledge has been gained regarding how GPCRs are activated in β cells, less is known about the mechanisms controlling their deactivation. In many cell types, terminatio...