SREBP1 regulates Lgals3 activation in response to cholesterol loading

• Váldodahkkit: Jing Li (Dahkki), Hongtao Shen (Dahkki), Gary K. Owens (Dahkki), Lian-Wang Guo (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2022-06-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Aberrant smooth muscle cell (SMC) plasticity is etiological to vascular diseases. Cholesterol induces SMC phenotypic transition featuring high LGALS3 (galectin-3) expression. This proatherogenic process is poorly understood for its molecular underpinnings, in particular, the mechanistic role of ster...