Discovery of the anti-angiogenesis effect of eltrombopag in breast cancer through targeting of HuR protein

• Main Authors: Yuying Zhu (Author), Liuqing Yang (Author), Jiazhen Xu (Author), Xiyan Yang (Author), Pengwei Luan (Author), Qianfei Cui (Author), Pei Zhang (Author), Feiyun Wang (Author), Ruixiang Li (Author), Xinyue Ding (Author), Lixian Jiang (Author), Guoqiang Lin (Author), Jiange Zhang (Author)
• Format: Book
• Published: Elsevier, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HuR (human antigen R), an mRNA-binding protein responsible for poor prognosis in nearly all kinds of malignancies, is a potential anti-tumor target for drug development. While screening HuR inhibitors with a fluorescence polarization (FP) based high-throughput screening (HTS) system, the clinically...