Discovery of the anti-angiogenesis effect of eltrombopag in breast cancer through targeting of HuR protein

• मुख्य लेखकों: Yuying Zhu (लेखक), Liuqing Yang (लेखक), Jiazhen Xu (लेखक), Xiyan Yang (लेखक), Pengwei Luan (लेखक), Qianfei Cui (लेखक), Pei Zhang (लेखक), Feiyun Wang (लेखक), Ruixiang Li (लेखक), Xinyue Ding (लेखक), Lixian Jiang (लेखक), Guoqiang Lin (लेखक), Jiange Zhang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2020-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

HuR (human antigen R), an mRNA-binding protein responsible for poor prognosis in nearly all kinds of malignancies, is a potential anti-tumor target for drug development. While screening HuR inhibitors with a fluorescence polarization (FP) based high-throughput screening (HTS) system, the clinically...