The Mitochondrial-Derived Peptide MOTS-c Alleviates Radiation Pneumonitis via an Nrf2-Dependent Mechanism

• Main Authors: Yanli Zhang (Author), Jianfeng Huang (Author), Yaru Zhang (Author), Fengjuan Jiang (Author), Shengpeng Li (Author), Shuai He (Author), Jiaojiao Sun (Author), Dan Chen (Author), Ying Tong (Author), Qingfeng Pang (Author), Yaxian Wu (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Radiation pneumonitis (RP) is a prevalent and fatal complication of thoracic radiotherapy due to the lack of effective treatment options. RP primarily arises from mitochondrial injury in lung epithelial cells. The mitochondrial-derived peptide MOTS-c has demonstrated protective effects against vario...