Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug-Drug Interactions in Rats

Gadoxetate, a magnetic resonance imaging (MRI) contrast agent, is a substrate of organic-anion-transporting polypeptide 1B1 and multidrug resistance-associated protein 2. Six drugs, with varying degrees of transporter inhibition, were used to assess gadoxetate dynamic contrast enhanced MRI biomarker...

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Main Authors: Nicola Melillo (Author), Daniel Scotcher (Author), J. Gerry Kenna (Author), Claudia Green (Author), Catherine D. G. Hines (Author), Iina Laitinen (Author), Paul D. Hockings (Author), Kayode Ogungbenro (Author), Ebony R. Gunwhy (Author), Steven Sourbron (Author), John C. Waterton (Author), Gunnar Schuetz (Author), Aleksandra Galetin (Author)
Format: Book
Published: MDPI AG, 2023-03-01T00:00:00Z.
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