Cumingianoside A, a Phyto-Triterpenoid Saponin Inhibits Acquired BRAF Inhibitor Resistant Melanoma Growth via Programmed Cell Death

• Main Authors: Biljana Cvetanova (Author), Ya-Ching Shen (Author), Lie-Fen Shyur (Author)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Mutated proto-oncogene BRAF is a bona fide therapeutic target for melanomas. Regrettably, melanoma acquires resistance to BRAF inhibitors, e.g., vemurafenib (PLX4032) casting doubt on this promising melanoma targeted therapy. In this study, we explored the bioactivity of triterpenoid saponin cumingi...