Characterization of an N-terminal Nav1.5 channel variant - a potential risk factor for arrhythmias and sudden death?

• Main Authors: Stefanie Scheiper-Welling (Author), Paolo Zuccolini (Author), Oliver Rauh (Author), Britt-Maria Beckmann (Author), Christof Geisen (Author), Anna Moroni (Author), Gerhard Thiel (Author), Silke Kauferstein (Author)
• 格式: 圖書
• 出版: BMC, 2020-11-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Abstract Background Alterations in the SCN5A gene encoding the cardiac sodium channel Nav1.5 have been linked to a number of arrhythmia syndromes and diseases including long-QT syndrome (LQTS), Brugada syndrome (BrS) and dilative cardiomyopathy (DCM), which may predispose to fatal arrhythmias and su...