SOD1 in ALS: Taking Stock in Pathogenic Mechanisms and the Role of Glial and Muscle Cells

• Main Authors: Caterina Peggion (Author), Valeria Scalcon (Author), Maria Lina Massimino (Author), Kelly Nies (Author), Raffaele Lopreiato (Author), Maria Pia Rigobello (Author), Alessandro Bertoli (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still unclear, the discovery that familial cases of ALS are related to mutations in the Cu/Zn superoxide dismutase (SOD...