Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia

• Main Authors: Belen Rivero-Gutierrez (Author), April Haller (Author), Jenna Holland (Author), Emily Yates (Author), Radha Khrisna (Author), Kirk Habegger (Author), Richard Dimarchi (Author), David D'Alessio (Author), Diego Perez-Tilve (Author)
• Format: Book
• Published: Elsevier, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Mice with congenital loss of the glucagon receptor gene (Gcgr−/− mice) remain normoglycemic in insulinopenic conditions, suggesting that unopposed glucagon action is the driving force for hyperglycemia in Type-1 Diabetes Mellitus (T1DM). However, chronic loss of GCGR results in a neomorph...